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Index > Protein center > S100b(Gene name) > Rat
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  • S100b (Gene name),
  • Protein S100-B (Protein name ),  S100B_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    S100b;
    Protein name:
    Protein S100-B;
    Alternative:
    S-100 protein subunit beta;S-100 protein beta chain;S100 calcium-binding protein B;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer interacts with two molecules of CAPZA1. The S100B dimer interacts with two molecules of STK38. Interacts with AGER.
    Function:
    Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    92
    Sequence:
    50:
    MSELEKAMVA | LIDVFHQYSG | REGDKHKLKK | SELKELINNE | LSHFLEEIKE | 
    92:
    QEVVDKVMET | LDEDGDGECD | FQEFMAFVSM | VTTACHEFFE | HE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Protein S100-B
    Cat.:
    E0567h
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    96T
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    ELISA Kit for Rat Protein S100-B
    Cat.:
    E0567r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Protein S100-B
    Cat.:
    E0567m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Protein S100-B
    Cat.:
    E0567b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Protein S100-B
    MSDS:
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    CLIA Kit for Rat Protein S100-B
    Cat.:
    U0567h
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Protein S100-B
    Cat.:
    U0567m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Protein S100-B
    Cat.:
    U0567r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Protein S100-B
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Protein S100-B
    Cat.:
    U0567b
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat Protein S100-B
    Polyclonal Antibody for Rat Protein S100-B
    Cat.:
    P0567Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Protein S100-B
    Cat.:
    P0567Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Protein S100-B
    Polyclonal Antibody for Rat Protein S100-B
    Cat.:
    P0567Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Protein S100-B
    Monoclonal Antibody for Rat Protein S100-B
    Monoclonal Antibody for Rat Protein S100-B
    Monoclonal Antibody for Rat Protein S100-B
    Monoclonal Antibody for Rat Protein S100-B
    Protein for Rat Protein S100-B
    Cat.:
    R0567h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat Protein S100-B
    Protein for Rat Protein S100-B
    Protein for Rat Protein S100-B
    Protein for Rat Protein S100-B

    R&D Technical Data

     12% SDS-PAGE analysis

    ? ? ? ??12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and the complete nucleotide sequence of cDNA to mRNA for S-100 protein of rat brain."
      Kuwano R. , Usui H. , Maeda T. , Fukui T. , Yamanari N. , Ohtsuka E. , Ikehara M. , Takahashi Y.
      Nucleic Acids Res.12:7455-7465(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular cloning and nucleotide sequences of cDNA and genomic DNA for alpha and beta subunits of S100 protein."
      Kuwano R. , Usui H. , Maeda T. , Araki K. , Kurihara T. , Yamakuni T. , Ohtsuka E. , Ikehara M. , Takahashi Y.
      Taniguchi Symp. Brain Sci.19:243-255(1987)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Structure and expression of rat S-100 beta subunit gene."
      Maeda T. , Usui H. , Araki K. , Kuwano R. , Takahashi Y. , Suzuki Y.
      Brain Res. Mol. Brain Res.10:193-202(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Heart.
    5. 5.
      "Reduction in S100 protein beta subunit mRNA in C6 rat glioma cells following treatment with anti-microtubular drugs."
      Dunn R. , Landry C. , O'Hanlon D. , Dunn J. , Allore R. , Brown I. , Marks A.
      J. Biol. Chem.262:3562-3566(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-92
    6. 6.
      Lubec G. , Afjehi-Sadat L. , Kang S.U.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-21 AND 35-56;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
      tissue: Spinal cord.
    7. 7.
      "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."
      Filipek A. , Jastrzebska B. , Nowotny M. , Kuznicki J.
      J. Biol. Chem.277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CACYBP
    8. 8.
      "S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction."
      Tsoporis J.N. , Izhar S. , Leong-Poi H. , Desjardins J.F. , Huttunen H.J. , Parker T.G.
      Circ. Res.106:93-101(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AGER;INDUCTION
    9. 9.
      "The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A."
      Gilquin B. , Cannon B.R. , Hubstenberger A. , Moulouel B. , Falk E. , Merle N. , Assard N. , Kieffer S. , Rousseau D. , Wilder P.T. , Weber D.J. , Baudier J.
      Mol. Cell. Biol.30:2724-2736(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ATAD3A
    10. 10.
      "Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy."
      Drohat A.C. , Amburgey J.C. , Abildgaard F. , Starich M.R. , Baldisseri D.M. , Weber D.J.
      Biochemistry35:11577-11588(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    11. 11.
      "Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy."
      Drohat A.C. , Baldisseri D.M. , Rustandi R.R. , Weber D.J.
      Biochemistry37:2729-2740(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    12. 12.
      "The use of dipolar couplings for determining the solution structure of rat apo-S100B."
      Drohat A.C. , Tjandra N. , Baldisseri D.M. , Weber D.J.
      Protein Sci.8:800-809(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    13. 13.
      "Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12."
      Inman K.G. , Yang R. , Rustandi R.R. , Miller K.E. , Baldisseri D.M. , Weber D.J.
      J. Mol. Biol.324:1003-1014(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR IN COMPLEX WITH CAPZA1 AND CALCIUM
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